Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19Research article Published on 2022-11-012022-10-05 Journal: Bioorganic chemistry [Category] SARS, 신약개발, [키워드] activities activity addition Anti-inflammatory antioxidant Cell Co-receptor consequence COVID-19 CRP derivatives DPPH Effect evaluated IL-6 infections molecular docking not correlated novel OGT Patient Pyrimidinones question raised SARS-CoV-2 screened small molecule drug tested therapy Treatment type 2 diabete type 2 diabetes [DOI] 10.1016/j.bioorg.2022.106092 [Article Type] Research article
Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과Article Published on 2022-05-042022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal intestinal barrier. intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus [DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article
SARS-CoV-2: Receptor and Co-receptor Tropism ProbabilitySARS-CoV-2: 수용체 및 공동 수용체 방향성 확률Review Published on 2022-03-162022-09-11 Journal: Current microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 distribution acute respiratory syndrome addition Amino acid amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 attachment binding broad spectrum caused cells cellular cellular component China Co-receptor coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 disease domain entry of SARS-CoV-2 extreme facilitate Factor first stage help heterogeneous Host host cell hosts humans infect mechanisms membrane molecular organs pandemic Pathogenesis pathogenesis of COVID-19 pathogenic virus Perspective Prevent protease Proteases public health RBD receptor Receptor-binding domain receptor-binding domains receptors required SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severity Spike protein Spike proteins susceptibilities the SARS-CoV-2 the spike protein tissues Treatment strategies tropism understanding virus entry [DOI] 10.1007/s00284-022-02807-7 PMC 바로가기 [Article Type] Review
Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies폐렴 세포는 COVID-19 부검에서 SARS-CoV-2의 공동 수용체인 ER 스트레스 바이오마커 GRP78의 고도로 상승된 발현으로 구별됩니다Article Published on 2021-09-012022-09-11 Journal: Cell stress & chaperones [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory distress syndrome age alveolar damage ARDS Autopsy Biomarker cellular Co-receptor controls COVID-19 COVID-19 patient death rate death rates Deceased Degradation determined by distress edema elevated ER stress examined exhibited expression feature Gender Glucose GRP78 Host hyaline membrane hyaline membrane formation immune modulation immunohistochemical staining immunostaining implicated independent independent of Inflammation Interaction lung Lung injury Lungs Macrophage macrophages modulate morbidity morbidity and mortality Non-COVID-19 nucleocapsid protein overlap overlapped pathway pneumocyte Pneumocytes Protein Proteostasis receptor reducing Resilience respiratory distress Respiratory distress syndrome robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe lung injury staining surgical resection syndrome therapeutic strategy tissue repair unfolded protein response Unfolded protein response. UPR Vaccinations was increased [DOI] 10.1007/s12192-021-01230-4 PMC 바로가기 [Article Type] Article
Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronavirusesArticle Published on 2020-05-212023-07-13 Journal: Biochemical and Biophysical Research Communication [Category] SARS, [키워드] ACE2 Co-receptor Coronaviruses Macrophage SARS-CoV-2 scRNA-seq. [DOI] 10.1016/j.bbrc.2020.03.044 PMC 바로가기